Cancer Risks forMLH1andMSH2Mutation Carriers
نویسندگان
چکیده
منابع مشابه
Cancer risks after endometrial cancer in mismatch repair mutation carriers.
Recent years have seen increasing attention to the management of endometrial cancer risk in families with hereditary nonpolyposis colorectal cancer or Lynch syndrome (HNPCC/LS). Nevertheless, because endometrial cancer is less common and carries a lower mortality (1) than colorectal cancer in mismatch repair gene (MMR) mutation carriers, it may be an afterthought for many providers and patients...
متن کاملLifetime cancer risks of PTEN mutation carriers--letter.
We read with interest the recent article by Tan and colleagues (1), summarizing their experience in germline PTEN genetic testing. There is certainly a need for information about lifetime cancer risks for individuals with deleterious PTEN mutations and the authors’ data set will be helpful in defining this phenotype. However, the very high lifetime cancer risks they reported are not consistent ...
متن کاملThe lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations.
Several studies using families with multiple occurrences of breast cancer have provided evidence for a very high lifetime penetrance in carriers of BRCA1 or BRCA2 mutations. However, there are reasons to suspect that the estimates of penetrance from studies of cancer families may be inflated. Access to the genotypes of incident cases of breast cancer in three hospitals and from a large series o...
متن کاملModifiers of breast and ovarian cancer risks for BRCA1 and BRCA2 mutation carriers.
Pathogenic mutations in BRCA1 and BRCA2 are associated with high risks of breast and ovarian cancer. However, penetrance estimates for mutation carriers have been found to vary substantially between studies, and the observed differences in risk are consistent with the hypothesis that genetic and environmental factors modify cancer risks for women with these mutations. Direct evidence that this ...
متن کاملCancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE.
BACKGROUND Reliable estimates of cancer risk are critical for guiding management of BRCA1 and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for breast cancer, ovarian cancer, and contralateral breast cancer in a prospective series of mutation carriers and to assess how these risks are modified by common breast cancer susceptibility alleles. METHODS Prospe...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2013
ISSN: 1059-7794
DOI: 10.1002/humu.22262